Dr. Dipnarine Maharaj
Dr. Dipnarine Maharaj
Tuesday, December 10, 2013
Stem Cell Treatment and Childhood Type 2 Diabetes
Please visit this new website www.childhoodtype2diabetes.com . It is a great resource for Childhood Type 2 Diabetes.
Sunday, September 8, 2013
Diabetes - By Dr. Dipnarine Maharaj MD
Diabetes
THE ROOT CAUSE OF DIABETES IS INFLAMMATION.
What is Diabetes?
Diabetes is the condition in which the body does not properly process food for use as energy. Most of the food we eat is turned into glucose, or sugar, for our bodies to use for energy. The pancreas, an organ that lies near the stomach, makes a hormone called insulin to help glucose get into the cells of our bodies. When you have diabetes, your body either doesn’t make enough insulin or can’t use its own insulin as well as it should. This causes sugars to build up in your blood. This is why many people refer to diabetes as “sugar.” Diabetes can cause serious health complications including heart disease, blindness, kidney failure, and lower-extremity amputations. Diabetes is the seventh leading cause of death in the United States.
Diabetes is the seventh leading cause of death in the United States. Characterized by unusually high levels of sugar glucose in the bloodstream, it is responsible for much of the complications of the disease, including liver disease and stroke.
How can Stem Cells help treat Diabetes?
Today, new treatments and advances in research are giving new hope to people affected by diabetes. Adult stem cells have been shown to be precursors to embryonic and islet stem cells that produce insulin. However any and all stem cell treatments are considered experimental and should only be done under the supervision of a licensed and trained specialist. With more research and treatment, soon new breakthroughs will help patients with diabetes.
Thursday, August 22, 2013
Wednesday, August 14, 2013
The Disease of Diabetes - By Dipnarine Maharaj
The Disease of Diabetes:
By Dipnarine Maharaj
Diabetes mellitus, often simply referred to as diabetes—is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced. This high blood sugar produces the classical symptoms of polyuria (frequent urination), polydipsia (increased thirst) and polyphagia (increased hunger).
There are two main types of diabetes: Type 1 diabetes: results from the body's failure to produce insulin, and presently requires the person to inject insulin. (Also referred to as insulin-dependent diabetes mellitus, IDDM for short, and juvenile diabetes.) Type 2 diabetes: results from insulin resistance, a condition in which cells fail to use insulin properly, sometimes combined with an absolute insulin deficiency. (Formerly referred to as non-insulin-dependent diabetes mellitus, NIDDM for short, and adult-onset diabetes.)
Other forms of diabetes mellitus include congenital diabetes, which is due to genetic defects of insulin secretion, cystic fibrosis-related diabetes, steroid diabetes induced by high doses of glucocorticoids, and several forms of monogenic diabetes.
All forms of diabetes have been treatable since insulin became available in 1921, and type 2 diabetes may be controlled with medications. Both type 1 and 2 are chronic conditions that usually cannot be cured. Pancreas transplants have been tried with limited success in type 1 DM; gastric bypass surgery has been successful in many with morbid obesity and type 2 DM. Gestational diabetes usually resolves after delivery. Diabetes without proper treatments can cause many complications. Acute complications include hypoglycemia, diabetic ketoacidosis, or nonketotic hyperosmolar coma. Serious long-term complications include cardiovascular disease, chronic renal failure, retinal damage. Adequate treatment of diabetes is thus important, as well as blood pressure control and lifestyle factors such as smoking cessation and maintaining a healthy body weight.
Pathology: Insulin is the principal hormone that regulates uptake of glucose from the blood into most cells (primarily muscle and fat cells, but not central nervous system cells). Therefore deficiency of insulin or the insensitivity of its receptors plays a central role in all forms of diabetes mellitus.
Humans are capable of digesting some carbohydrates, in particular those most common in food; starch, and some disaccharides such as sucrose, are converted within a few hours to simpler forms most notably the monosaccharide glucose, the principal carbohydrate energy source used by the body. The rest are passed on for processing by gut flora largely in the colon. Insulin is released into the blood by beta cells (?-cells), found in the Islets of Langerhans in the pancreas, in response to rising levels of blood glucose, typically after eating. Insulin is used by about two-thirds of the body's cells to absorb glucose from the blood for use as fuel, for conversion to other needed molecules, or for storage.
Insulin is also the principal control signal for conversion of glucose to glycogen for internal storage in liver and muscle cells. Lowered glucose levels result both in the reduced release of insulin from the beta cells and in the reverse conversion of glycogen to glucose when glucose levels fall. This is mainly controlled by the hormone glucagon which acts in the opposite manner to insulin. Glucose thus forcibly produced from internal liver cell stores (as glycogen) re-enters the bloodstream; muscle cells lack the necessary export mechanism. Normally liver cells do this when the level of insulin is low (which normally correlates with low levels of blood glucose).
Higher insulin levels increase some anabolic ("building up") processes such as cell growth and duplication, protein synthesis, and fat storage. Insulin (or its lack) is the principal signal in converting many of the bidirectional processes of metabolism from a catabolic to an anabolic direction, and vice versa. In particular, a low insulin level is the trigger for entering or leaving ketosis (the fat burning metabolic phase).
If the amount of insulin available is insufficient, if cells respond poorly to the effects of insulin (insulin insensitivity or resistance), or if the insulin itself is defective, then glucose will not have its usual effect so that glucose will not be absorbed properly by those body cells that require it nor will it be stored appropriately in the liver and muscles. The net effect is persistent high levels of blood glucose, poor protein synthesis, and other metabolic derangements, such as acidosis.
When the glucose concentration in the blood is raised beyond its renal threshold (about 10 mmol/L, although this may be altered in certain conditions, such as pregnancy), reabsorption of glucose in the proximal renal tubuli is incomplete, and part of the glucose remains in the urine (glycosuria). This increases the osmotic pressure of the urine and inhibits reabsorption of water by the kidney, resulting in increased urine production (polyuria) and increased fluid loss. Lost blood volume will be replaced osmotically from water held in body cells and other body compartments, causing dehydration and increased thirst.
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By Dipnarine Maharaj
Diabetes mellitus, often simply referred to as diabetes—is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced. This high blood sugar produces the classical symptoms of polyuria (frequent urination), polydipsia (increased thirst) and polyphagia (increased hunger).
There are two main types of diabetes: Type 1 diabetes: results from the body's failure to produce insulin, and presently requires the person to inject insulin. (Also referred to as insulin-dependent diabetes mellitus, IDDM for short, and juvenile diabetes.) Type 2 diabetes: results from insulin resistance, a condition in which cells fail to use insulin properly, sometimes combined with an absolute insulin deficiency. (Formerly referred to as non-insulin-dependent diabetes mellitus, NIDDM for short, and adult-onset diabetes.)
Other forms of diabetes mellitus include congenital diabetes, which is due to genetic defects of insulin secretion, cystic fibrosis-related diabetes, steroid diabetes induced by high doses of glucocorticoids, and several forms of monogenic diabetes.
All forms of diabetes have been treatable since insulin became available in 1921, and type 2 diabetes may be controlled with medications. Both type 1 and 2 are chronic conditions that usually cannot be cured. Pancreas transplants have been tried with limited success in type 1 DM; gastric bypass surgery has been successful in many with morbid obesity and type 2 DM. Gestational diabetes usually resolves after delivery. Diabetes without proper treatments can cause many complications. Acute complications include hypoglycemia, diabetic ketoacidosis, or nonketotic hyperosmolar coma. Serious long-term complications include cardiovascular disease, chronic renal failure, retinal damage. Adequate treatment of diabetes is thus important, as well as blood pressure control and lifestyle factors such as smoking cessation and maintaining a healthy body weight.
Pathology: Insulin is the principal hormone that regulates uptake of glucose from the blood into most cells (primarily muscle and fat cells, but not central nervous system cells). Therefore deficiency of insulin or the insensitivity of its receptors plays a central role in all forms of diabetes mellitus.
Humans are capable of digesting some carbohydrates, in particular those most common in food; starch, and some disaccharides such as sucrose, are converted within a few hours to simpler forms most notably the monosaccharide glucose, the principal carbohydrate energy source used by the body. The rest are passed on for processing by gut flora largely in the colon. Insulin is released into the blood by beta cells (?-cells), found in the Islets of Langerhans in the pancreas, in response to rising levels of blood glucose, typically after eating. Insulin is used by about two-thirds of the body's cells to absorb glucose from the blood for use as fuel, for conversion to other needed molecules, or for storage.
Insulin is also the principal control signal for conversion of glucose to glycogen for internal storage in liver and muscle cells. Lowered glucose levels result both in the reduced release of insulin from the beta cells and in the reverse conversion of glycogen to glucose when glucose levels fall. This is mainly controlled by the hormone glucagon which acts in the opposite manner to insulin. Glucose thus forcibly produced from internal liver cell stores (as glycogen) re-enters the bloodstream; muscle cells lack the necessary export mechanism. Normally liver cells do this when the level of insulin is low (which normally correlates with low levels of blood glucose).
Higher insulin levels increase some anabolic ("building up") processes such as cell growth and duplication, protein synthesis, and fat storage. Insulin (or its lack) is the principal signal in converting many of the bidirectional processes of metabolism from a catabolic to an anabolic direction, and vice versa. In particular, a low insulin level is the trigger for entering or leaving ketosis (the fat burning metabolic phase).
If the amount of insulin available is insufficient, if cells respond poorly to the effects of insulin (insulin insensitivity or resistance), or if the insulin itself is defective, then glucose will not have its usual effect so that glucose will not be absorbed properly by those body cells that require it nor will it be stored appropriately in the liver and muscles. The net effect is persistent high levels of blood glucose, poor protein synthesis, and other metabolic derangements, such as acidosis.
When the glucose concentration in the blood is raised beyond its renal threshold (about 10 mmol/L, although this may be altered in certain conditions, such as pregnancy), reabsorption of glucose in the proximal renal tubuli is incomplete, and part of the glucose remains in the urine (glycosuria). This increases the osmotic pressure of the urine and inhibits reabsorption of water by the kidney, resulting in increased urine production (polyuria) and increased fluid loss. Lost blood volume will be replaced osmotically from water held in body cells and other body compartments, causing dehydration and increased thirst.
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Tuesday, August 6, 2013
Walking, cycling to work may curb diabetes risk - Recommended by Dr. Dipnarine Maharaj M.D. FACP
Walking, cycling to work may curb diabetes risk - Recommended by Dr. Dipnarine Maharaj M.D. FACP
http://www.cbsnews.com/8301-204_162-57597236/walking-cycling-to-work-may-curb-diabetes-risk/
By
Michelle Castillo /
CBS News/ August 6, 2013, 2:55 PM Walking, cycling to work may curb diabetes risk
Do you walk to work? Your daily jaunt may be cutting your risk of developing Type 2 diabetes by about 40 percent.
A new study published in the American Journal of Preventative Medicine on Aug. 6 looked at the various methods people use to get to work and how it impacted their health. Not surprisingly, driving was not the top way to protect against obesity and chronic disease.
Researchers surveyed 20,000 people across the U.K. for the study. They found that people who cycled, walked and used public transportation were less likely to be overweight than those who drove.
About 19 percent of responders who used a private mode of transportation for their work travel -- including cars, motorbikes or taxis -- were obese. Only 15 percent of walkers and 13 percent of cyclists, however, were obese.
The researchers found other health benefits. Cyclists were about 50 percent less likely to have diabetes compared to drivers. People who walked to work were 40 percent less likely to have diabetes and 17 percent less likely to have high blood pressure compared to those who took their cars.
"This study highlights that building physical activity into the daily routine by walking, cycling or using public transport to get to work is good for personal health ," study co-author Anthony Laverty, a research assistant at the School of Public Health at Imperial College London, said in a press release.
About 25.8 million children and adults in the U.S. have diabetes, the American Diabetes Association reports. Type 2 diabetes, the most common form of the disease, is a condition in which the body cannot correctly use a hormone called insulin, which helps regulate the amount of sugar in blood.
One out of three American adults has high blood pressure or hypertension, according to the Centers for Disease Control and Prevention.
Obesity is a risk factor for both of those diseases. The CDC reports that more than one-third of U.S. adults are obese.
Recent research also shows that walking offers protective health benefits. Short 15-minute walks after meals have been shown to lower the risk of Type 2 diabetes. An April 2013 study showed that walking may be just as good as running when it comes to heart benefits.
Alas, the CDC reports that 80 percent of U.S. adults don't get the recommended weekly amount of physical activity. The agency advises at least 2.5 hours of moderate-intensity aerobic exercise each week, one hour and 15 minutes of vigorous-intensity activity or a combination of both. Adults should also engage in muscle-strengthening activities like lifting weights or doing push-ups at least twice per week.
"We are recommended to have at least 30 minutes' moderate exercise a day so only a 15-minute walk at either end and you have done your quota -- although the longer the better," Millett said. "It's also more convenient than going to the gym because it can be factored in as part of your day without having to set aside any other time."
© 2013 CBS Interactive Inc. All Rights Reserved.A new study published in the American Journal of Preventative Medicine on Aug. 6 looked at the various methods people use to get to work and how it impacted their health. Not surprisingly, driving was not the top way to protect against obesity and chronic disease.
Researchers surveyed 20,000 people across the U.K. for the study. They found that people who cycled, walked and used public transportation were less likely to be overweight than those who drove.
About 19 percent of responders who used a private mode of transportation for their work travel -- including cars, motorbikes or taxis -- were obese. Only 15 percent of walkers and 13 percent of cyclists, however, were obese.
The researchers found other health benefits. Cyclists were about 50 percent less likely to have diabetes compared to drivers. People who walked to work were 40 percent less likely to have diabetes and 17 percent less likely to have high blood pressure compared to those who took their cars.
"This study highlights that building physical activity into the daily routine by walking, cycling or using public transport to get to work is good for personal health ," study co-author Anthony Laverty, a research assistant at the School of Public Health at Imperial College London, said in a press release.
About 25.8 million children and adults in the U.S. have diabetes, the American Diabetes Association reports. Type 2 diabetes, the most common form of the disease, is a condition in which the body cannot correctly use a hormone called insulin, which helps regulate the amount of sugar in blood.
One out of three American adults has high blood pressure or hypertension, according to the Centers for Disease Control and Prevention.
Obesity is a risk factor for both of those diseases. The CDC reports that more than one-third of U.S. adults are obese.
- Watching your avatar be healthy may help with weight loss
- Diet, exercise for Type 2 diabetics may not lower heart attack risk
Recent research also shows that walking offers protective health benefits. Short 15-minute walks after meals have been shown to lower the risk of Type 2 diabetes. An April 2013 study showed that walking may be just as good as running when it comes to heart benefits.
Alas, the CDC reports that 80 percent of U.S. adults don't get the recommended weekly amount of physical activity. The agency advises at least 2.5 hours of moderate-intensity aerobic exercise each week, one hour and 15 minutes of vigorous-intensity activity or a combination of both. Adults should also engage in muscle-strengthening activities like lifting weights or doing push-ups at least twice per week.
"We are recommended to have at least 30 minutes' moderate exercise a day so only a 15-minute walk at either end and you have done your quota -- although the longer the better," Millett said. "It's also more convenient than going to the gym because it can be factored in as part of your day without having to set aside any other time."
http://www.cbsnews.com/8301-204_162-57597236/walking-cycling-to-work-may-curb-diabetes-risk/
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Diabetes Clinical Trial - Dr. Dipnarine Maharaj
Diabetes Clinical Trial - Dr. Dipnarine Maharaj
The Stem Cell Cancer Regenerative Medicine Research
Foundation Inc. is seeking funding for research to uncover the inflammatory
basis of degenerative diseases such as Diabetes Mellitus and to determine
whether treating the inflammation will play a crucial role in altering the
underlying biology of this disease which affects 24 million people in the
United States and 241 million people worldwide.
 |
| Diabetes Expert Dr. Dipnarine Maharaj M.D. FACP |
The goals of the Stem Cell Cancer Regenerative Medicine Research Foundation Inc. Is dedicated to taking actions that will: predict those patients at risk for development of the disease before the actual clinical onset, to prevent the disease; and study the use of stem cells for tissue repair.
The Stem Cell Cancer Regenerative Medicine Research Foundation’s support of the research being conducted by the South Florida Bone Marrow Stem Cell Transplant Institute under the direction of Medical Director, Dipnarine Maharaj, MD, FACP.
Wednesday, July 31, 2013
Dipnarine Maharaj - The Diabetes Clinical Trial Project:
The Diabetes Clinical Trial Project:
The South Florida Bone Marrow Stem Cell Transplant Institute would like to
conduct a Diabetes Clinical Trial under the direction of Medical Director,
Dipnarine Maharaj, MD, FACP. The Diabetes Clinical Trial will involve the
treatment of 60 diabetic patients ( 30 Type 1 & 30 Type 2) through a stem cell mobilization
treatment. Patient participants will be required to participate in
initial screening processes before acceptance in the clinical trial to ensure
that they are healthy enough to undergo the treatment protocol.
The patients selected to participate in the Diabetes Clinical Trial will undergo a series of stem cell mobilization treatments with stem cells for a period of 42 days(6 weeks). Follow-up visits with the physician as well as all tests and examinations will be included as part of the Clinical Trial so that there is no cost to the patient participant.
 |
| Diabetes Expert Dr. Dipnarine Maharaj M.D. |
The patients selected to participate in the Diabetes Clinical Trial will undergo a series of stem cell mobilization treatments with stem cells for a period of 42 days(6 weeks). Follow-up visits with the physician as well as all tests and examinations will be included as part of the Clinical Trial so that there is no cost to the patient participant.
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